<p>Hi David<br>
I have had the same problem with a Coolscan IV ED. And my Epson scanner worked just fine with VueScan. After reading the Q&A on the CoolScan site, I tried using another USB cable and a port on the computer. Then the Coolscan worked fine too. And the 'old' cable and port worked with other devices.<br>
My conclusion is that the Coolscan is more sensitive to issues with the USB connection than any other device I have used. <br>
Good luck.</p>