@ David. I qualified my comment by saying "with the same framing".
I am currently shooting this lens with the 7D and 6D, so this is my observation. A subject you need 3x on for crop you may
need to go to 5x on the full frame. Tbh result are not so different, but at lower magnifications the full frame has the edge.
Of course managing the working distance and interference of your flash rig on the surroundings gets harder at high
magnification.
On the 6D I have done some sucsesfuly natural light work handheld up to about 3x, great for subjects like the Green Tiger
Beetle where flash would have to be very heavily diffused to be acceptable.