I routinely scan 35mm slides at the maximum resolution of my scanner (5400ppi), so as to get as much detail off the slide as possible. However, in 16bit mode, this creates unwieldy files that are about 215Mb in size. After editing in Photoshop with multiple layers, the files can easily exceed 1Gb in size. What is the best way to deal with such huge files? Is it always best to edit at maximum size and then resample/resize for final output, or is resizing before editing acceptable? The latter approach could be problematic if multiple output sizes are required, either at the time of initial scanning or in the future. I guess what I am seeking is a proper workflow for handling and storing my scans. Any advice will be appreciated.