Maybe Vuescan is the way to go? I recently downloaded the latest version and got outstanding results straight off my Primefilm scanner - after a little playing with the settings. WRT the settings for the Coolscan. Nearly every Windows program has a .ini or config file that dictates its startup conditions. If you can find that and edit it, you should be able to change the default preferences. Maybe the .ini file has been moved or write-protected during Windows update? There are known issues with OHCI (firewire) driver versions from Win7 onwards, that MS has been reluctant (or too lazy) to address. They're mostly fixed by using Device Manager to 'update' the OHCI driver to the legacy version. However I doubt that the firewire driver is responsible for disallowing changes to the preferences dialogue.