I had seen some reports that this was true, but after buying a D300 and making the comparison now I know for myself. There is so much hype around the D300 and it's ISO capabilities, it's hard to know what is what. What I found, comparing RAW images in Lightroom with no NR, was that the D50 is better at both ISO 200 and 1600 than the D300. The D50 is close to noise free at 200, but the D300 is definitely not. At 1600 I expected the D300 to be better, but it's just not the case. I tried resizing the ISO 200 D300 image to a 6MP image, the same as the D50, and then the noise is basically the same between the two. Slight edge to the D300, as the resolution of the resized D300 image seemed better than the original D50 image if I looked at fine text which was just below the resolution limit of the D50. Anyway, I just wanted to post this. If I had known this beforehand I might not have bought the D300.