Since starting to use Lightroom recently, I decided that I liked its image manipulation controls much better than Vuescan's, and so for my color negatives I'd like to get a basic scan from Vuescan and then do the more extensive work in Lightroom. This is what I'm doing now: Lock the exposure and base color in Vuescan Scan my film. I use Vuescan's RGB histograms to set the black and white points for each image, and I tweak the overall white balance to get it in the ballpark. I leave the contrast low. Output full-size 48-bit TIFFs from Vuescan. Import those into Lightroom for further work. I noticed that Vuescan also has a DNG raw output option. Thinking that might be better, I tried it, but when I import the DNGs into Lightroom, the image is still inverted. (And yes, I do have Vuescan set to color negative mode.) So my questions are: Is there any point in worrying about this, or are the 48-bit TIFFs just as good as what I'd get from the raw DNGs, assuming I could make them work. Would the DNGs save any disk space? Is there a way to invert the colors in Lightroom? If not, is there a way to get Vuescan to output a raw DNG but with the color inverted? I currently have Vuescan's dust-and-scratch removal enabled and that is reflected in the TIFFs, but I'd be willing to give that up and do the spotting by hand in Lightroom if there was an advantage to using the DNGs.