<p>I use the Epson Scan software when scanning 35mm transparencies on my V500 and get perfectly fine results. I use Epson Scan in Professional Mode, Document Type = Film, The 'Film Type' choices include 'Positive Film' (slides), 'Color Negative Film' and 'B&W Negative Film'. The default Target Size is 'Original'. When I use the supplied slide or negative holder and click on the Preview button, I get a set of identically sized preview images. An Epson flatbed scanner is never going to produce the same results as a dedicated film scanner, but I've gotten some pretty impressive scans from sharp transparencies.</p>